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KMID : 1009020230210010010
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Clinical Psychopharmacology and Neuroscience
2023 Volume.21 No. 1 p.10 ~ p.18
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The Clinical Observation of Inflammation Theory for Depression: The Initiative of the Formosa Long COVID Multicenter Study (FOCuS)
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Liu Shu Tsen
Lin Sheng Che
Chang Jane Pei Chen
Yang Kai Jie
Chu Che Sheng
Yang Chia Chun
Liang Chih Sung
Sun Ching Fang
Wang Shao Cheng
Satyanarayanan Senthil Kumaran
Su Kuan Pin
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Abstract
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There is growing evidence that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risks of psychiatric sequelae. Depression, anxiety, cognitive impairments, sleep disturbance, and fatigue during and after the acute phase of COVID-19 are prevalent, long-lasting, and exerting negative consequences on well-being and imposing a huge burden on healthcare systems and society. This current review presented timely updates of clinical research findings, particularly focusing on the pathogenetic mechanisms underlying the neuropsychiatric sequelae, and identified potential key targets for developing effective treatment strategies for long COVID. In addition, we introduced the Formosa Long COVID Multicenter Study (FOCuS), which aims to apply the inflammation theory to the pathogenesis and the psychosocial and nutrition treatments of post-COVID depression and anxiety.
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KEYWORD
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COVID-19, Depression, Neuropsychiatric sequelae, Inflammation, Long COVID, Post-acute COVID-19 syndrome
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